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The Effects of Nicotine Exposure
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The Aerosol You Inhale
![If you vape, you could be damaging your lungs with toxic metals.](/sites/default/files/styles/masthead_product_mobile_1x/public/images/masthead/masthead-img-p-mobile/mscroscopic-masthead-mobile_0.jpg?itok=cjk4gJ5Z 1x)
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Vapes: Macroscopic Metals
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Macroscopic Metals Campaign
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Williams M, Villarreal A, Bozhilov K, Lin S, Talbot P. Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PLoS One. 2013; 8(3):e57987.
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Olmedo P, Goessler W, Tanda S, et al. Metal concentrations in e-cigarette liquid and aerosol samples: the contribution of metallic coils. Environmental Health Perspectives (Online). 2018; 126(2).
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National Academies of Sciences, Engineering, and Medicine (NASEM). 2018. Public Health Consequences of E-cigarettes. Washington, DC: The National Academies Press. Doi: https://doi.org/10.17226/24952
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Sommerfeld CG, Weiner DJ, Nowalk A. Larkin A. Hypersensitivity Pneumonitis and Acute Respiratory Distress Syndrome From E-Cigarette Use. Pediatrics. 2018; 141(6):e20163927.
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Khan, MS, Khateeb F, Akhtar J, Khan Z, Lal A, Kholodovych V, Hammersley J. Organizing pneumonia related to electronic cigarette use: A case report and review of literature. The clinical respiratory journal. 2018; 12(3):1295-1299.
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The Effects of Nicotine Exposure
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U.S. Department of Health and Human Services. E-Cigarette Use Among Youth and Young Adults. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2016
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Hiler M, Breland A, et al. Electronic cigarette user plasma nicotine concentration, puff topography, heart rate, and subjective effects: Influence of liquid nicotine concentration and user experience. Exp Clin Psychopharmacol. 2017; 25(5)380-392.
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Jackler RK & Ramamurthi D. Nicotine arms race: JUUL and the high-nicotine product market. Tob Control. Published Online First: 06 February 2019. doi: 10.1136/tobaccocontrol-2018-054796.
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Prochaska JJ, Vogel EA, Benowitz N. Nicotine delivery and cigarette equivalents from vaping a JUULpod. Tobacco Control 2022;31:e88-e93.
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Vapes: Q&A macroscopic-metals
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U.S. Department of Health and Human Services. E-Cigarette Use Among Youth and Young Adults. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2016
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Jackler RK & Ramamurthi D. Nicotine arms race: JUUL and the high-nicotine product market. Tob Control. Published Online First: 06 February 2019. doi: 10.1136/tobaccocontrol-2018-054796.
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Connor DA, Gould TJ. Chronic fluoxetine ameliorates adolescent chronic nicotine exposure-induced long-term adult deficits in trace conditioning. Neuropharmacology. 2017; 125:272-283.
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Holliday ED, Gould TJ. Chronic Nicotine Treatment During Adolescence Attenuates the Effects of Acute Nicotine in Adult Contextual Fear Learning. Nicotine & Tobacco Research. 2017; 19(1):87-93.
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Counotte DS, Spijker S, Van de Burgwal LH, et al. Long-lasting cognitive deficits resulting from adolescent nicotine exposure in rats. Neuropsychopharmacology. 2009; 34(2):299-306.
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Fountain SB, Rowan JD, Kelley BM, Willey AR, Nolley EP. Adolescent exposure to nicotine impairs adult serial pattern learning in rats. Exp Brain Res. 2008; 187(4):651-656.
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National Academies of Sciences, Engineering, and Medicine (NASEM). 2018. Public Health Consequences of E-cigarettes. Washington, DC: The National Academies Press. Doi: https://doi.org/10.17226/24952
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U.S. Department of Health and Human Services (USDHHS). A Report of the Surgeon General: Preventing Tobacco Use among Youth and Young Adults. We Can Make the Next Generation Tobacco-Free (Consumer Booklet). Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2012.
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U.S. Department of Health and Human Services (USDHHS). Preventing Tobacco Use Among Youth and Young Adults (Fact Sheet). Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2012.
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Trauth JA, Seidler FJ, Ali SF, Slotkin TA. Adolescent nicotine exposure produces immediate and long-term changes in CNS noradrenergic and dopaminergic function. Brain Research. 2001; 892(2):269-280.
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Williams M, Villarreal A, Bozhilov K, Lin S, Talbot P. Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PLoS One. 2013; 8(3):e57987.
-
Olmedo P, Goessler W, Tanda S, et al. Metal concentrations in e-cigarette liquid and aerosol samples: the contribution of metallic coils. Environmental Health Perspectives (Online). 2018; 126(2).
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Food and Drug Administration (FDA). Harmful and potentially harmful constituents in tobacco products and tobacco smoke: established list. Federal Register. 2012; 77(64): 20034-20037.
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https://www.fda.gov/tobacco-products/products-ingredients-components/vaporizers-e-cigarettes-and-other-electronic-nicotine-delivery-systems-ends
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Rubinstein M, Delucchi K, Benowitz N, Ramo D. Adolescent exposure to toxic volatile organic chemicals from e-cigarettes. Pediatrics. 2018; 141(4):e20173557.
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Metal Particles Found in Vapes
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Cheng T. Chemical evaluation of electronic cigarettes. Tobacco Control. 2014; 23:ii11–ii17.
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Williams M, Villarreal A, Bozhilov K, Lin S, Talbot P. Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PLoS One. 2013; 8(3):e57987.
-
Olmedo P, Goessler W, Tanda S, et al. Metal concentrations in e-cigarette liquid and aerosol samples: the contribution of metallic coils. Environmental Health Perspectives (Online). 2018; 126(2).
-
Food and Drug Administration (FDA). Harmful and potentially harmful constituents in tobacco products and tobacco smoke: established list. Federal Register. 2012; 77(64): 20034-20037.
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The Aerosol You Inhale
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U.S. Department of Health and Human Services. E-Cigarette Use Among Youth and Young Adults. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2016
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National Academies of Sciences, Engineering, and Medicine (NASEM). 2018. Public Health Consequences of E-cigarettes. Washington, DC: The National Academies Press. Doi: https://10.17226/24952
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Cao Y, Wu D, Ma Y, Ma X, Wang S, Li F, Li M, Zhang T. Toxicity of electronic cigarettes: A general review of the origins, health hazards, and toxicity mechanisms. Sci. Total Environ. 2021 Jun 10;772:145475.
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Rubinstein M, Delucchi K, Benowitz N, Ramo D. Adolescent exposure to toxic volatile organic chemicals from e-cigarettes. Pediatrics. 2018; 141(4):e20173557.
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Occupational Safety and Health Administration (OSHA). Occupational Safety and Health Standards. Medical surveillance – Formaldehyde. Washington, DC: U.S. Department of Labor, Occupational Safety and Health Administration. https://www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=STANDARDS&p_id=10078. Accessed May 8, 2018.
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Goniewicz ML, Knysak J, Gawron M, et al. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tobacco Control. 2014; 23(2):133-139.
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U.S. Department of Health and Human Services (USDHHS). Smoking Cessation. A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2020.
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